The 80th Major League Baseball All Star Game was held on July 14, 2009 at the new Busch Stadium in St Louis, Missouri in front of 46,760 fans. The American League beat the National League by a score of 4-3 in just 2 hours and 31 minutes, the shortest All Star Game in over 20 years. President Barack Obama threw out the ceremonial first pitch. Carl Crawford of the Tampa Bay Rays was the most valuable player. The National League has not beat the American League since 1996.

From 1966 to 2005, Busch Memorial Stadium in St. Louis, Missouri was home to the National League St. Louis Cardinals baseball team. The stadium featured a design of 96 arches know as the "Crown of Arches," which echoed the design of the Gateway Arch. Other teams to call the stadium home were the St. Louis Cardinals and Rams NFL teams and the St. Louis Stars soccer team. Demolition of the stadium began on November 7, 2005. The Cardinals now play in a new stadium by the same name.